S19-04 Cardiac regeneration in the zebrafish model system
نویسندگان
چکیده
Regeneration is a trait observed in various metazoans to differing extents. We are interested in how some species manage to regenerate complex structures and why this ability has been lost in other species. Among vertebrates, the salamanders have the most impressive regenerative abilities that includes appendage and spinal cord regeneration as well as regeneration of a number of organs such as the heart. An important question is to what extent cells revert to a primitive embryonic state in order to restart the process of regenerating a complex structure such as the limb or tail. Do cells become multior pluri-potent? Having developed germline transgenesis in this animal, we are able to track different cell types during limb and tail regeneration. From such studies, we show that cells do not become pluripotent during limb regeneration but rather display properties of tissuerestricted progenitors probably similar to those present in the limb bud. In the spinal cord, we present evidence that spinal cord amputation causes cells revert to an embryonic neuroepitheliallike state in order to restart spinal cord growth.
منابع مشابه
Establishing a new animal model for muscle regeneration studies
Skeletal muscle injuries are one of the most common problems in the worldwide which impose a substantial financial burden to the health care system. Accordingly, it widely accepted that muscle regeneration is a promising approach that can be used to treat muscle injury patients. However, the underlying mechanisms of muscle regeneration have yet to be elucidated. The muscle structure and muscle...
متن کاملMechanisms of spinal cord injury regeneration in zebrafish: a systematic review
Objective(s):To determine the molecular and cellular mechanisms of spinal cord regeneration in zebrafish. Materials and Methods: Medical databases of PubMed and Scopus were searched with following key words: Zebrafish; spinal cord injuries; regeneration; recovery of function. The map of mechanisms was performed using Xmind software. Results: Wnt/ß-catenin signaling, L1.1, L1.2, Major vault prot...
متن کاملDedifferentiation, Transdifferentiation, and Proliferation: Mechanisms Underlying Cardiac Muscle Regeneration in Zebrafish
The adult mammalian heart is increasingly recognized as a regenerative organ with a measurable capacity to replenish cardiomyocytes throughout its lifetime, illuminating the possibility of stimulating endogenous regenerative capacity to treat heart diseases. Unlike mammals, certain vertebrates possess robust capacity for regenerating a damaged heart, providing a model to understand how regenera...
متن کاملAdvanced Echocardiography in Adult Zebrafish Reveals Delayed Recovery of Heart Function after Myocardial Cryoinjury
Translucent zebrafish larvae represent an established model to analyze genetics of cardiac development and human cardiac disease. More recently adult zebrafish are utilized to evaluate mechanisms of cardiac regeneration and by benefiting from recent genome editing technologies, including TALEN and CRISPR, adult zebrafish are emerging as a valuable in vivo model to evaluate novel disease genes a...
متن کاملDistinct effects of inflammation on preconditioning and regeneration of the adult zebrafish heart
The adult heart is able to activate cardioprotective programmes and modifies its architecture in response to physiological or pathological changes. While mammalian cardiac remodelling often involves hypertrophic expansion, the adult zebrafish heart exploits hyperplastic growth. This capacity depends on the responsiveness of zebrafish cardiomyocytes to mitogenic signals throughout their entire l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009